Evidence map›Paper›PMID 42274175›Full record

ArticleJACC. Case reports2026

Pyramidal Angulation of the Ascending Aortic Graft: Recurrent Emboli After Type A Repair.

Naomi Timmermans, Kayan Lam, Pieter-Jan Vlaar, Thomas van Brakel

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Naomi TimmermansDepartment of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: n.m.a.j.timmermans-7@umcutrecht.nl.
Kayan LamDepartment of Cardiothoracic Surgery, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.
Pieter-Jan VlaarDepartment of Cardiothoracic Surgery, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.
Thomas van BrakelDepartment of Cardiothoracic Surgery, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe report a unique case of recurrent cerebrovascular events under adequate anticoagulation, in the absence of a visible thrombus, due to a severely kinked ascending aortic graft after type A dissection repair. CASE SUMMARY: A 70-year-old man developed 4 transient ischemic attacks and 3 ischemic strokes over 4 years despite therapeutic rivaroxaban levels and prior antiplatelet therapy. Imaging revealed a kinked ascending graft without thrombus. High-risk redo surgery was pursued to correct graft geometry, after which no further embolic events occurred during early follow-up (5 months). DISCUSSION: This case addresses the clinical dilemma whether a visible thrombus is required to justify redo surgery after type A repair, especially when recurrent embolism occurs under maximal medical therapy. TAKE-HOME MESSAGE: Surgical correction of graft kinking may be indicated-even in the absence of a thrombus-when embolic risk persists under optimal anticoagulation.

Indexed as

anticoagulationaortic dissectionascending aorta graftembolic strokegraft kinkingredo surgery

Identifiers

PMID42274175
PMCPMC13261946

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.