Evidence map›Paper›PMID 42274100›Full record

SynthesisInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026

Impact of ovarian preservation on survival for premenopausal women with early-stage endometrial carcinoma: A systematic review and meta-analysis.

Antonio Raffone, Diego Raimondo, Daniele Neola, Manuela Maletta, Marisol Doglioli, Antonio Travaglino, Carlo Ronsini, Maria Giovanna Vastarella, Stefano Ferla, Francesco Cosentino and 3 more

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Impact of ovarian preservation on survival for premenopausal women with early-stage endometrial carcinoma: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Antonio RaffoneDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Diego RaimondoDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Daniele NeolaDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0001-6723-0415
Manuela MalettaDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Marisol DoglioliDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Antonio TravaglinoUnit of Pathology, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy.
Carlo RonsiniDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Maria Giovanna VastarellaDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Stefano FerlaDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Francesco CosentinoGynecologic Oncology and Surgery Unit, Responsible Research Hospital, Campobasso, Italy.
Pasquale De FranciscisDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Renato SeracchioliDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Luigi CobellisDepartment of Woman, Child, and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUp to 14% of women with early-stage endometrial carcinoma (EEC) are diagnosed before menopause. Although ovarian preservation (OP) within surgical staging might avoid surgical menopause, its rate remains low in clinical practice, probably because the impact of OP on survival outcomes is unclear. This study evaluates the impact of OP on (i) survival outcomes, (ii) adverse events, and (iii) quality of life (QoL) in young women with EEC.

methodA systematic review and meta-analysis was performed searching seven electronic databases from their inception to 2022. The study included all randomized controlled trials (RCTs) and non-randomized comparative studies (NRS) comparing survival outcomes of women who underwent OP versus bilateral salpingo-oophorectomy (BSO). Primary outcome was the risk of death of any cause, while secondary outcomes were the risk of death due to endometrial carcinoma, the risk of recurrent disease, adverse events after ovarian surgery, and QoL.

resultsTwelve studies were included in the qualitative synthesis, while nine studies with a total of 115 528 women were suitable for the quantitative analysis. Compared to the BSO group, the OP group had a hazard ratio of 0.805 (95% confidence interval [CI]: 0.655-0.989) for death of any cause, 1.079 (95% CI: 0.395-2.953) for death due to endometrial carcinoma, and 1.332 (95% CI: 0.663-2.674) for recurrent disease. No pooled data were obtainable for adverse events after ovarian surgery and QoL.

conclusionIn young women with EEC, our study seems to support the OP at the time of surgical treatment as it appears to reduce the risk of death of any cause by approximately 20%, with no impact on the risk of death due to endometrial carcinoma and the risk of recurrent disease. However, given the risk of bias of the included studies, further well-designed studies are needed.

Indexed as

CarcinomaEndometrial NeoplasmsOrgan Sparing TreatmentsOvaryAdultFemaleHumansNeoplasm StagingPremenopauseQuality of LifeRandomized Controlled Trials as TopicSalpingo-oophorectomycancercardiovascular riskendometriumhealthnon‐alcoholic fatty liver diseaseosteoporosisuterus

Identifiers

PMID42274100
PMCPMC13674844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.