Evidence map›Paper›PMID 42273871›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Association of cognitive impairment and APOE ε4 with Centiloids in Hispanic and non-Hispanic White cohorts.

Cally Xiao, Tyler Ard, Ganna Blazhenets, Renaud La Joie, Ioannis Pappas, Arthur W Toga, Alzheimer's Disease Neuroimaging Initiative, Health and Aging Brain Study (HABS‐HD) Study Team

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Association of cognitive impairment and APOE ε4 with Centiloids in Hispanic and non-Hispanic White cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cally XiaoLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-7172-3175
Tyler ArdLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Ganna BlazhenetsEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Renaud La JoieEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Ioannis PappasLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Alzheimer's Disease Neuroimaging Initiative
Health and Aging Brain Study (HABS‐HD) Study Team

Funding

Alzheimer's Association SG-20-678486-GAAIN2
6 · The paper itself

Abstract

introductionWeak associations of apolipoprotein E (APOE) ε4 with cognitive impairment have been reported in Hispanic cohorts. To determine if APOE ε4 associates with brain amyloid load differently in Hispanic and non-Hispanic White (NHW) cohorts, we analyzed reported Centiloid values from studies that conducted amyloid positron emission tomography.

methodsThis meta-analysis included 17,017 participants (8.4% Hispanic) from five source studies. Analysis of covariance and logistic regression models adjusting for age, sex, education, and cognitive score were applied.

resultsAlthough cognitive impairment and APOE ε4 were associated with higher Centiloids in both Hispanic and NHW cohorts, cognitively impaired and APOE ε4 positive Hispanic participants had lower Centiloids than NHW participants with the same conditions. DISCUSSION: APOE ε4 may have a weaker influence on brain amyloid load in Hispanic cohorts. Further comparative analyses are necessary for Alzheimer's disease anti-amyloid treatments to be widely applicable to Hispanic populations.

Indexed as

Apolipoprotein E4BrainCognition DisordersCognitive DysfunctionHispanic or LatinoWhiteAgedCohort StudiesFemaleHumansMalePositron-Emission TomographyApolipoprotein E4amyloidAPOEbiomarkerCentiloiddementiaethnicityHispanicMCIneuroimagingPET

Identifiers

PMID42273871
PMCPMC13254819

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.