Evidence map›Paper›PMID 42273832›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings.

Sreya Dhanam, Mark Sanderson-Cimino, Jack Carson Taylor, Emily W Paolillo, Ray Fregly, Winnie Kwang, Paul Maruff, Amy Wise, Hilary W Heuer, Leah K Forsberg and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Sreya DhanamDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID https://orcid.org/0009-0000-3194-2170
Mark Sanderson-CiminoDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Jack Carson TaylorDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Emily W PaolilloDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Ray FreglyDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Winnie KwangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Paul MaruffThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Amy WiseDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Hilary W HeuerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Leah K ForsbergDepartment of Neurology USA, Mayo Clinic, Rochester, Minnesota, USA.
Joel H KramerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Bradley F BoeveDepartment of Neurology USA, Mayo Clinic, Rochester, Minnesota, USA.
Howard J RosenDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
R Scott MackinVA Advanced Research Center, San Francisco, California, USA.
Michael W WeinerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
Rachel L NoshenyVA Advanced Research Center, San Francisco, California, USA.
Adam L BoxerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-3903-9805
Adam M StaffaroniDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, California, USA.
and the Brain Health Registry

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI ADAM L. BOXER, Bradley F Boeve · 2019 to 2026
$120.9M
The Brain Health Registry for facilitating interdisciplinary aging researchR33AG062867 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOSHENY, RACHEL LAUREN · 2020 to 2024
$3.2M
Bluefield Project to Cure FTDNIA NIH HHS R33 AG062867NIH HHS AG077557NIH HHS R33AG062867NIH HHS U19AG063911The Rainwater Charitable Foundation
6 · The paper itself

Abstract

backgroundRemote, smartphone-based cognitive testing may improve access to cognitive assessments for Alzheimer's disease and related dementias. We evaluated the feasibility, reliability, and validity of unsupervised smartphone-based cognitive tests in a registry-based cohort.

methodsAdults without a record of cognitive impairment (N = 1815; ages 18-92) were recruited from the University of California, San Francisco (UCSF) Brain Health Registry to complete three unsupervised smartphone cognitive testing sessions within 2 weeks. Reliability was assessed with correlations between sessions. Linear regression models tested associations of smartphone tasks with demographics, self- and informant-rated cognitive concerns, and web-based cognitive testing (Cogstate Brief Battery).

resultsAdherence was high (82.2%) and usability favorable. Test-retest reliability was moderate to strong (ρ's = 0.61-0.85, all p's < 0.001). Lower smartphone scores were associated with older age, lower education, cognitive concerns, and worse Cogstate performance. DISCUSSION: Findings support the feasibility, reliability, and validity of remote digital assessments in adults without a record of cognitive impairment.

Indexed as

Cognitive DysfunctionNeuropsychological TestsSmartphoneAdolescentAdultAgedAged, 80 and overCohort StudiesFeasibility StudiesFemaleHumansMaleMiddle AgedRegistriesReproducibility of ResultsYoung AdultALLFTD Mobile AppAlzheimer's diseasecomposite scoreDatacubed Healthdigital biomarkersdigital healthearly detectionfeasibilitylinkt appneuropsychologyreliabilityremote assessmentsvalidity

Identifiers

PMID42273832
PMCPMC13254688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.