Evidence map›Paper›PMID 42273736›Full record

ArticleBioscience reports2026

MCM2-7 proteins promote NF-κB transcriptional activity through cooperative promoter recruitment.

Xian Hong, Ming Sui, Qiang Li, Yan-Ji Lu, Yong-Hong Nie, Yong-Pei Li, Wen-Long Li, Xin-Xin Yue, Jing Xu, Daniel Billadeau and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xian HongLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Ming SuiLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Qiang LiLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Yan-Ji LuLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Yong-Hong NieLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Yong-Pei LiLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Wen-Long LiLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Xin-Xin YueLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.
Jing XuDepartment of Gastroenterology, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161006, China.
Daniel BilladeauDivision of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, U.S.A.
Tao WangLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.ORCID 0000-0002-4837-6854
Zhi-Hui DengLaboratory of Protein Structure and Function, Institute of Medicine and Pharmacy, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.

Funding

Construction Project of Dominant Characteristic Disciplines of Qiqihar Medical University QYZDXK-003Education Department Foundation of Heilongjiang Province 2025-KYYWF-ZR0986Heilongjiang Provincial Natural Science Foundation of China PL2025C097National Natural Science Foundation of China 32071409Program for Outstanding Youth Science and Technology Innovation Talent of Qiqihar Medical University QYZYQN-202602Qiqihar Medical Institute Foundation 2025-ZDPY-002Qiqihar Medical Institute Foundation QMSI2024M-10Qiqihar Medical Institute Foundation YNZX2026-05Scientific technology Project of Qiqihar City LSFGG-2024099
6 · The paper itself

Abstract

The minichromosome maintenance 2-7 (MCM2-7) proteins form a hexameric protein complex that is the structural core of replicative helicase, which is essential for accurate DNA replication. While their role in replication is well-established, the biological functions of excess chromatin-bound MCM2-7 proteins remain unclear. Here, we identify a transcriptional regulatory function of MCM2-7 through its interaction with nuclear factor κB (NF-κB) p65. We demonstrate that MCM2-7 proteins and NF-κB p65 reciprocally recruit each other to target gene promoters. Consequently, MCM2-7 proteins facilitate the localization of RNA Pol II to NF-κB target gene promoters and along the gene body, thereby promoting transcription of NF-κB target genes. These findings reveal MCM2-7 proteins promote NF-κB target gene transcription by facilitating p65 and RNA Pol II recruitment, offering a potential avenue for fine-tuning NF-κB target gene transcription.

Indexed as

Minichromosome Maintenance ProteinsPromoter Regions, GeneticTranscription Factor RelATranscription, GeneticHumansNF-kappa BRNA Polymerase IIMinichromosome Maintenance ProteinsNF-kappa BRELA protein, humanRNA Polymerase IITranscription Factor RelAMCM2-7 proteinsNF-κBRNA polymerase IItranscription initiation

Identifiers

PMID42273736
PMCPMC13305959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.