In one paragraphArticle in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Zhenyu Xiong *Department of Cardiology, Sixth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China (Z.X., Y.L., J. Liu, Y.C.).ORCID 0009-0007-6633-6147 Yueyang Li *Department of Cardiology, Sixth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China (Z.X., Y.L., J. Liu, Y.C.).ORCID 0000-0002-8220-5530 Yan Zhang *Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0000-0002-6314-4146 Zhengjun MaDepartment of Ultrasound Diagnosis, No. 941 Hospital of Joint Logistics Support Force, Xining, China (Z.M.).ORCID 0009-0002-5099-5934 Meiying QiDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0009-0008-9045-5135 Huanle ZhangDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0009-0002-5188-9324 Xiaohua ZhangDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0009-0002-1707-6346 Mengyuan JiangDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0000-0003-0508-9916 Jie LiuDepartment of Cardiology, Sixth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China (Z.X., Y.L., J. Liu, Y.C.).ORCID 0009-0008-2015-1590 Erhe GaoCenter for Translational Medicine, Temple University, Philadelphia, PA (E.G.).
Congye LiDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0000-0001-9443-1642 Wanrong ManDepartment of Cardiology, General Hospital of Western Theater Command of Chinese PLA, Chengdu, China (W.M.).ORCID 0000-0002-2015-7473 Mingming ZhangDepartment of Cardiology, Tangdu Hospital, Air Force Medical University, Xi' an, China (M.Z., J.H.).ORCID 0000-0001-8480-0280 Jianqiang HuDepartment of Cardiology, Tangdu Hospital, Air Force Medical University, Xi' an, China (M.Z., J.H.).ORCID 0000-0003-1568-3521 Jie LinDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0009-0008-6431-7046 Zhi YangDepartment of Radiation Oncology, General Hospital of Southern Theater Command of Chinese PLA, Guangzhou, China (Z.Y.).ORCID 0000-0003-2377-3113 Li FanDepartment of Pharmaceutical Chemistry and Analysis, Air Force Medical University, Xi' an, China (L.F.).ORCID 0000-0001-9387-1275 Yundai ChenDepartment of Cardiology, Sixth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China (Z.X., Y.L., J. Liu, Y.C.).ORCID 0000-0003-4409-9375 Dongdong SunDepartment of Cardiology, Xijing Hospital, Air Force Medical University, Xi' an, China (Y.Z., M.Q., H.Z., X.Z., M.J., C.L., J. Lin, D.S.).ORCID 0000-0003-2147-3977 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundMetabolic disturbances are key contributors to myocardial ischemia-reperfusion (I/R) injury, yet the underlying molecular mechanisms remain largely unclear. Rho family GTPase 3 (RND3), a cytosolic small guanosine triphosphatase (GTPase) known to antagonize ROCK1 (Rho-associated coiled-coil kinase 1), has been implicated in several cardiovascular disorders. However, its mitochondrial localization and functional role in cardiac energy metabolism and I/R injury remain unknown.
methodsA murine model of myocardial I/R injury was established through left anterior descending coronary artery ligation. Mice with cardiomyocyte-specific knockout and overexpression of
resultsCardiomyocyte-specific deletion of
conclusionsOur results identify RND3 as a novel mitochondria-localized regulator of glucose oxidation that safeguards the heart against I/R injury. Therapeutic reconstitution of
Indexed as
Acetyl-CoA C-AcetyltransferaseGlucoseMyocardial Reperfusion InjuryPyruvate Dehydrogenase (Lipoamide)rho GTP-Binding ProteinsAcetylationAgedAnimalsDisease Models, AnimalEnergy MetabolismFemaleHeartHumansMaleMiceMice, KnockoutAcetyl-CoA C-AcetyltransferaseGlucosePyruvate Dehydrogenase (Lipoamide)rho GTP-Binding ProteinsRnd3 protein, mouseacetylationenergy metabolismmyocardial reperfusion injurypyruvate dehydrogenase complexrho GTP-binding proteins
Identifiers
PMID42273734
PMCPMC13340457
What OpenQuestion holds
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