ArticleFrontiers in immunology2026
Incremental diagnostic value of mycobacterium tuberculosis antigen-based skin test for active tuberculosis: a diagnostic accuracy study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: In WHO consolidated guidelines on tuberculosis (TB) for TB infection tests, studies to assess the diagnostic association for active TB compared with current infection tests were recommended as one of the priorities for future research. Previous research has indicated some clinical characteristics of Creation Tuberculin Skin Test (C-TST) which were different from Tuberculin Skin Tests (TST). Based on these new clinical characteristics, the research objective was to evaluate the incremental diagnostic value of C-TST for the diagnosis of active TB under specific conditions, compared with TST. Methods: This was a retrospective, non-randomized, exploratory diagnostic accuracy study. The incremental diagnostic value of C-TST above a certain cut-off point was evaluated in suspected Pulmonary Tuberculosis (PTB) cases, and was compared with TST, which was conducted in Chongqing between January 2022 and July 2024. Results: In 1553 suspected TB participants, 398 were tested using TST or C-TST. In active PTB cases, the median diameter of C-TST induration or erythema was significantly larger than that of TST induration ( Conclusions: At a specific cut-off value, C-TST shows preliminary exploratory potential for indicating active TB among adult suspected PTB cases. Further external and prospective validation is still warranted to confirm its clinical diagnostic utility.
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