ArticleFrontiers in immunology2026
Systemic immune responses in patients with spine surgery related infections.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Surgical site infections (SSIs) are significant complications that can occur after spine surgery. Compared with systemic infections such as sepsis, or localised musculoskeletal infections such as periprosthetic joint infection, the immune responses in postoperative infection of the spine are poorly understood. A deeper understanding may provide clinically relevant diagnostic or therapeutic options. Methods: This study examined changes in immune cell profiles in the blood of patients who developed infections after spinal surgery (Infection group, I, Results: Cluster analysis identified 46 immune cell clusters, 30 of which exhibited significant differences between the I and NI patients. Natural killer cells as well as myeloid dendritic cells were decreased in I patients compared to NI patients ( Discussion: This study reveals that patients with SSI exhibit a significantly altered immune cell profile, with greatest differences observed in increased HLA-DR
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