Evidence map›Paper›PMID 42273681›Full record

ArticleFrontiers in immunology2026

Ligature-induced periodontitis in mice potentially accelerates CD4

Jinfeng Li, Terukazu Sanui, Miyu Shida, Karen Yotsumoto, Mwannes Ahmad, Ziyu Wang, Meng Xiao, Chikako Hayashi, Takanori Shinjo, Takaharu Taketomi and 2 more

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jinfeng LiDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Terukazu SanuiDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Miyu ShidaDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Karen YotsumotoDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Mwannes AhmadDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Ziyu WangDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Meng XiaoDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Chikako HayashiDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Takanori ShinjoDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Takaharu TaketomiDental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Takao FukudaDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Fusanori NishimuraDepartment of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Aging impairs immunity, sustains chronic inflammation, and enhances autoimmunity-a process termed "immunosenescence" that contributes to the pathogenesis of type 2 diabetes and rheumatoid arthritis (RA). Post-pubertal thymic involution depletes naïve T-cell pool, promoting the emergence of senescent CD4 Methods: BALB/c mice (5-42 weeks old) underwent silk ligation of the maxillary second molars to induce experimental periodontitis (LIP). Splenic CD4 Results: Although the frequency of PD-1 Conclusions: These findings suggest that severe periodontal inflammation induces a "senescence-primed" status in the helper T cells. These senescent cells may enter systemic circulation and exacerbate RA, highlighting a novel cellular mechanism linking periodontitis to systemic disease.

Indexed as

Arthritis, RheumatoidCD4-Positive T-LymphocytesPeriodontitisT-Cell SenescenceAnimalsCellular SenescenceDisease Models, AnimalLymphocyte ActivationMaleMiceMice, Inbred BALB Cperiodontitisrheumatoid arthritissenescence-associated secretory phenotypesenescent CD4+ T cellsthymic involution

Identifiers

PMID42273681
PMCPMC13246652

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