Evidence map›Paper›PMID 42273660›Full record

ReviewArchives of medical sciences. Atherosclerotic diseases2026

Efficacy of torsemide versus furosemide in heart failure: a systematic review and meta-analysis of randomized controlled trials.

Mohamed Magdi Eid, Ahmed M Altibi, Mostafa Reda Mostafa, Andrew Takla, Ahmad Salem, Claudine Abdou, Majd Al Deen Alhuarrat, Devesh Rai, Wilbert S Aronow, Kirolos Barrsoum

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Archives of medical sciences. Atherosclerotic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed Magdi EidDepartment of Cardiology, Rochester Regional Health, Rochester, NY, USA.
Ahmed M AltibiDivision of Cardiology, Oregon Health and Science University, Portland, Oregon, USA.
Mostafa Reda MostafaDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York, USA.
Andrew TaklaDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York, USA.
Ahmad SalemDepartment of Internal Medicine, Rochester General Hospital, Rochester, New York, USA.
Claudine AbdouDepartment of Pharmacy, University of Rochester, Rochester, New York, USA.
Majd Al Deen AlhuarratDivision of Internal Medicine, NYC Health + Hospitals/Jacobi Medical Center, Albert Einstein College Medicine, Bronx, New York, USA.
Devesh RaiDepartment of Cardiology, Rochester Regional Health, Rochester, NY, USA.
Wilbert S AronowDepartment of Cardiology, Westchester Medical Center, Valhalla, NY, USA.
Kirolos BarrsoumUniversity of Texas Medical Branch, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Loop diuretics are a cornerstone in the symptomatic management of heart failure. There is conflicting evidence regarding potential differences between torsemide and furosemide in their effects on heart failure outcomes. Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to compare the therapeutic efficacy of furosemide versus torsemide in the management of heart failure. Methods: Medline/PubMed, Embase, and Cochrane Central Register of Controlled Trials were queried for studies comparing furosemide to torsemide in heart failure from inception to January 2023. Outcomes of interest included all-cause mortality, hospitalization due to heart failure, and weight change. Results: Our analysis included 10 RCTs comprising 4011 patients, of whom 2019 were treated with furosemide and 1992 patients were treated with torsemide. There was no significant difference between the groups in terms of all-cause mortality (OR = 0.99; 95% CI: 0.97-1.02; Conclusions: Furosemide and torsemide have similar impacts on mortality, hospitalization due to heart failure, and weight change in patients with congestive heart failure.

Indexed as

furosemideheart failureloop diureticstorsemide

Identifiers

PMID42273660
PMCPMC13248750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.