ArticleFrontiers in psychiatry2026
Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cognitive control deficits are a core feature of adolescent major depressive disorder (MDD), yet the associated task-state neurophysiological mechanisms remain poorly characterized. This study investigated electrophysiological alterations in MDD using a Stroop color-word task. Methods: Twenty-two adolescents with MDD and fifteen age- and sex-matched healthy controls (HC) completed the task during 32-channel EEG recording. We analyzed P300 amplitude and latency, 1-30Hz power spectral density (PSD) in key cortical regions, and task-based functional connectivity using the phase locking value (PLV). A support vector machine (SVM) classifier with leave-one-out cross-validation was employed to assess the diagnostic utility of the multimodal features. Results: Relative to HC, the MDD group exhibited significantly prolonged incongruent trial reaction times, reduced P300 amplitude at centro-parietal electrodes (Oz, PO7, O2), and enhanced alpha/beta-band PSD in occipitotemporal regions. Functional connectivity analysis revealed a task-state shift from a frontoparietal to an occipitotemporal network. The multimodal SVM model achieved 86.49% classification accuracy (AUC = 0.86). Conclusion: Task-specific P300 hypoactivity, aberrant oscillatory dynamics, and functional network reorganization collectively distinguish adolescent MDD from HC. These findings provide convergent neurophysiological evidence for impaired cognitive control in MDD and highlight the potential of preliminary candidate EEG biomarkers for early identification, prognostic assessment, and monitoring treatment response in adolescent MDD.
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