ArticleFrontiers in psychiatry2026
Altered anterior cingulate cortex functional connectivity in treatment-naïve obsessive-compulsive disorder: a resting-state fMRI study.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the anterior cingulate cortex (ACC) resting-state functional connectivity patterns in OCD patients who have not yet received therapy and analyze how they relate to the intensity of their clinical symptoms. Methods: Resting-state fMRI data were acquired from 46 medication-naïve participants with OCD and 33 demographically comparable neurotypical control subjects. The region of focus for the seed-based whole-brain functional connectivity investigation was bilateral ACC. Relationships between aberrant connections and clinical characteristics measured by the Y-BOCS, HAMD-17, and HAMA were investigated using Pearson's correlation coefficient and partial correlation analysis. Results: Key findings (OCD patients vs. healthy controls): Increased functional connectivity (FC) in OCD patients: Right insula (Brodmann area 48), Right hippocampus (BA 20), Right fusiform gyrus (BA 37); Decreased FC involving the anterior cingulate cortex (ACC) with: Right supplementary motor area (SMA, BA 32), Left inferior frontal gyrus (IFG, BA 47) (AlphaSim corrected, P < 0.05). Clinical association: There was a significant positive relationship between Y-BOCS total scores (a measure of OCD symptom severity) and FC strength linking the left IFG to the ACC (r = 0.351, P = 0.017). In practical terms, greater symptom severity is associated with stronger coupling between these two regions. No other clear brain-behavior relationships were found in the other regions examined. Conclusion: Treatment-naïve OCD patients demonstrate distinct ACC functional connectivity alterations involving cognitive control, motor planning, and limbic processing regions. The specific association between left inferior frontal gyrus (IFG)-ACC connectivity and symptom severity suggests that this pathway may serve as a neurobiological marker for OCD pathophysiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.