ArticleJournal of orthopaedic case reports2026
Standardized Preparation and Multi-Site Application of Leukocyte-Poor Platelet-Rich Plasma in Arthroscopic Anterior Cruciate Ligament Reconstruction: A Technical Note with Early Functional Outcomes.
Article in Journal of orthopaedic case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The role of platelet-rich plasma (PRP) in anterior cruciate ligament (ACL) reconstruction remains controversial due to heterogeneity in preparation and application protocols. This technical note describes a standardized method for preparation of leukocyte-poor (LP) PRP, and its multi-site intraoperative application, along with favorable early functional outcomes in 15 cases. Materials and Methods: LP-PRP was prepared using a double-spin centrifugation technique with deliberate exclusion of the buffy coat to minimize leukocyte content. Approximately 30 mL of autologous blood was processed. PRP was applied at three sites - (1) graft soaking before insertion, injection into (2) femoral and tibial tunnels, and (3) Intra-articular injection after graft fixation. Results: Fifteen patients undergoing arthroscopic ACL reconstruction with hamstring autograft and LP PRP augmentation were evaluated. Early follow-up demonstrated rapid improvement in functional outcomes, with higher Lysholm, International Knee Documentation Committee, and Tegner scores within the initial post-operative period compared to expected recovery timelines. No PRP -related complications were observed. Conclusion: A reproducible protocol for LP-PRP preparation and multi-site delivery may contribute to enhanced early recovery following ACL reconstruction. Standardization of this technique may improve consistency of outcomes.
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