Evidence map›Paper›PMID 42273404›Full record

ArticlePNAS nexus2026

A transfer RNA inosine modification drives genome-wide synonymous recoding across human commensal bacterial families.

Christopher D Katanski, Chathuri Pathirage, Jennifer C Chang, Iva Veseli, Tyler J Smith, Marcus Foo, Yuan Wu, Yichen Hou, Hoang Anh V Tran, Dominika Rudzka and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christopher D KatanskiDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0002-1707-081X
Chathuri PathirageDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0003-1527-0882
Jennifer C ChangCenter for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0002-6175-1284
Iva VeseliHelmholtz Institute for Functional Marine Biodiversity, Oldenburg, Lower Saxony 26129, Germany.ORCID https://orcid.org/0000-0003-2390-5286
Tyler J SmithDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Marcus FooCommittee on Microbiology, University of Chicago, Chicago, IL 60637, USA.
Yuan WuDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0001-9805-2105
Yichen HouCommittee on Genomics, Genetics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.
Hoang Anh V TranDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0009-0000-6373-3859
Dominika RudzkaDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.
Wen ZhangDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0001-8577-2613
Mohammad Amin Bayat TorkDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0002-2944-046X
Karen LolansDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0003-1903-756X
Amy D WillisDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Weixin TangDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0002-5739-5416
A Murat ErenHelmholtz Institute for Functional Marine Biodiversity, Oldenburg, Lower Saxony 26129, Germany.ORCID https://orcid.org/0000-0001-9013-4827
Michael J FederleCenter for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID https://orcid.org/0000-0002-4554-543X
Kristin S KoutmouDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0002-7763-9262
Tao PanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.ORCID https://orcid.org/0000-0003-1096-8405

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inosine modification on transfer RNA (tRNA) anticodon (I34) is universally conserved in three kingdoms of life and critical to tRNA decoding capabilities. We found that tRNA

Indexed as

codon evolutiongenomicsinosinetRNA

Identifiers

PMID42273404
PMCPMC13249217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.