Evidence map›Paper›PMID 42273380›Full record

ReviewJournal of clinical and translational hepatology2026

Mechanisms and Prognostic Assessment Value of Thyroid Hormone in Liver Failure.

Hong Zhou, Hong Wu, Shao-Hui Su, Shan-Hong Tang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and translational hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hong ZhouDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Hong WuDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Shao-Hui SuDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Shan-Hong TangDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-6652-2942

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early and accurate prognostic assessment is crucial to avoid serious disease progression in patients with liver failure. Thyroid hormone is an important metabolic regulator involved in hepatic function. This review examines the pathophysiological regulation in detail of the hypothalamic-pituitary-thyroid axis in patients with liver failure and emphasizes the importance of thyroid profiling (thyroid-stimulating hormone, T3, and T4) in prognostic assessment and risk stratification. T3 can enhance liver regeneration. The clinical application of thyroid hormone replacement therapy in patients with acute-on-chronic liver failure complicated by non-thyroidal illness syndrome is controversial. This review aims to inform clinical practice regarding the relevance of thyroid hormone level assessment in liver failure and to provide novel insights into the prognostic evaluation and comprehensive care of liver failure complicated by thyroid dysfunction.

Indexed as

Acute-on-chronic liver failureLiver failureNon-thyroidal illness syndromePrognosisThyroid hormoneTriiodothyronine

Identifiers

PMID42273380
PMCPMC13247710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.