Evidence map›Paper›PMID 42273361›Full record

ArticleJournal of human immunity2026

A homozygous CTLA-4 variant causes CTLA-4 deficiency with severe immune dysregulation.

Mehmet Cihangir Catak, Salim Can, Satanay Hubrack, Feyza Bayram Catak, Asha Elmi, Royala Babayeva, Razin Amirov, Melek Yorgun Altunbas, Sevgi Bilgic Eltan, Deniz Ertem and 8 more

Abstract read
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Autosomal recessive A20 zinc finger 7 mutation is associated with early-onset lupus-like disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mehmet Cihangir CatakDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-1387-5653
Salim CanDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-3797-3001
Satanay HubrackDivision of Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar.ORCID https://orcid.org/0000-0003-1095-7386
Feyza Bayram CatakDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-7484-4383
Asha ElmiDivision of Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar.ORCID https://orcid.org/0009-0002-4585-5718
Royala BabayevaDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-1044-2174
Razin AmirovDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0009-0002-7026-2711
Melek Yorgun AltunbasDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-4832-2928
Sevgi Bilgic EltanDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-0561-3343
Deniz ErtemDivision of Pediatric Gastroenterology Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-4427-0569
Baris YilmazDepartment of Pediatric Hematology Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-6542-0570
Ahmet KocDepartment of Pediatric Hematology Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-7940-2640
Batu ErmanDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acıbadem University, İstanbul, Turkey.ORCID https://orcid.org/0000-0003-2180-7607
Emine BozkurtlarDepartment of Pathology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-1034-9236
Elif Karakoc-AydinerDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-4150-5200
Ahmet OzenDepartment of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-9065-1901
Bernice Lo *Division of Translational Medicine, Research Branch, Sidra Medicine, Doha, Qatar.ORCID https://orcid.org/0000-0002-1087-6845
Safa Baris *Department of Pediatric Allergy and Immunology, Faculty of Medicine, Marmara University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-4730-9422

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CTLA-4 is a critical immune checkpoint that maintains self-tolerance by regulating immune activation. Here, we describe the first case of homozygous CTLA-4 deficiency (

Identifiers

PMID42273361
PMCPMC13248891

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.