Evidence map›Paper›PMID 42273303›Full record

ArticleCirculation reports2026

Association of Weight Loss With Improvement in Metabolic Status Among People Eligible for the Specific Health Guidance Program.

Masachika Nishikawa, Yuta Suzuki, Toshiyuki Ko, Hidehiro Kaneko, Akira Okada, Norifumi Takeda, Hiroyuki Morita, Katsuhito Fujiu, Tatsuhiko Azegami, Kaori Hayashi and 7 more

Abstract read
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In one paragraph

Article in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Masachika NishikawaDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Yuta SuzukiDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Toshiyuki KoDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Hidehiro KanekoDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Akira OkadaDepartment of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo Tokyo Japan.
Norifumi TakedaDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Hiroyuki MoritaDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Katsuhito FujiuDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.
Tatsuhiko AzegamiDivision of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine Tokyo Japan.
Kaori HayashiDivision of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine Tokyo Japan.
Kaori KitaokaSection of Research Collaboration and Partnership, Center for Private-Public-Academic Collaboration Research, National Institutes of Biomedical Innovation, Health and Nutrition Osaka Japan.
Katsuyuki MiuraNCD Epidemiology Research Center, Shiga University of Medical Science Shiga Japan.
Yuji FuruiHealthcare Data Science Research Unit, Institute for Future Initiatives, The University of Tokyo Tokyo Japan.
Koichi NodeDepartment of Cardiovascular Medicine, Saga University Saga Japan.
Hideo YasunagaDepartment of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo Tokyo Japan.
Masaomi NangakuDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine Tokyo Japan.
Norihiko TakedaDepartment of Cardiovascular Medicine, The University of Tokyo Tokyo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While international guidelines recommend 5-10% body weight reduction, evidence characterizing the dose-response relationship between specific weight loss amounts and metabolic syndrome (MetS) resolution in real-world populations is limited. Methods and Results: In this retrospective study, we analyzed a large-scale health check-up database provided by DeSC Healthcare (Tokyo, Japan). We identified 37,256 individuals with baseline MetS eligible for the Specific Health Guidance (SHG) program (2014-2023). Logistic regression assessed the association between 1-year weight changes and subsequent MetS status. Weight loss was significantly linked to MetS resolution. Compared with weight maintenance, a weight loss of 2.0-2.9 kg showed an adjusted odds ratio (OR) of 0.45 (95% confidence interval [CI] 0.41-0.49), and a loss of ≥3.0 kg showed an OR of 0.19 (95% CI 0.18-0.21). These associations were consistent across age and sex subgroups. Secondary analyses confirmed significant improvements in waist circumference, blood pressure, lipid profiles, and HbA1c. Conclusions: Weight loss over 1 year is significantly associated with MetS resolution among SHG-eligible individuals. These findings support the validity of weight loss recommendations in the fourth phase of the SHG program and offer empirical data for future health guidance design.

Indexed as

EpidemiologyMetabolic syndromePrevention

Identifiers

PMID42273303
PMCPMC13249479

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.