ArticleFrontiers in bioengineering and biotechnology2026
Decellularized porcine vascular grafts: structural integrity and translational potential for allogeneic implantation.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Decellularized vascular grafts (DVGs) are a promising alternative to synthetic prostheses for applications requiring long-term patency and biological integration. Here, we assessed porcine decellularized carotid arteries as vascular grafts using a detergent-enzymatic protocol. We removed cellular components while preserving native extracellular matrix architecture. Histology and immunohistochemistry confirmed effective removal of endothelial and smooth muscle cells, with intact collagen and elastin. Residual DNA content (32.6 ± 5.8 ng/mg) fell below the 50 ng/mg immunogenicity threshold. Mechanical testing showed tensile properties and burst pressure comparable to native vessels.
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