ArticleProceedings of SPIE--the International Society for Optical Engineering2026
Axially Swept Light-Sheet Microscopy using scattering and fluorescence contrast mechanisms.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Label-Free and High-Throughput Quantification of Nanoparticle-Cell Interactions at the Single-Cell Level with Flow Cytometry.Analytical chemistry · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Light-sheet fluorescence microscopy (LSFM) has found numerous applications in the life sciences through its gentle, rapid and efficient volumetric imaging capabilities. It would be advantageous if its rapid 3D imaging capabilities could be extended to non-fluorescent contrast mechanisms such as light-scattering. Yet, the coherent illumination with a light-sheet can cause cross-interference from multiple scatterers. Consequently, this can lead to an object-variant point-spread function, which complicates image analysis. Here we show that by combining axially swept illumination with sparse, but strong scatterers can lead to 3D imaging of comparable quality to traditional fluorescent light-sheet microscopy. We leverage axial sweeping of a light-sheet to both record fluorescence and scattered signals in expanded breast cancer spheroids seeded with gold nanoparticles.
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