Evidence map›Paper›PMID 42273269›Full record

ArticleEnvironmental epigenetics2026

Prenatal humid heat exposure and cord blood extracellular vesicle microRNA profiles in a Ghanaian Pregnancy Cohort: GRAPHS.

Alison Lee, Seyram Kaali, Michelle Li, Mohammed Mujtaba Nuhu, Elena Colicino, Musah Osei, Darby Jack, Sule Awuni, Steven N Chillrud, Haotian Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alison LeeDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.ORCID https://orcid.org/0000-0001-5518-5442
Seyram KaaliKintampo Health Research Centre, Kintampo, Ghana.
Michelle LiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Mohammed Mujtaba NuhuKintampo Health Research Centre, Kintampo, Ghana.
Elena ColicinoDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.
Musah OseiKintampo Health Research Centre, Kintampo, Ghana.
Darby JackDepartment of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, NY 10032, United States.
Sule AwuniKintampo Health Research Centre, Kintampo, Ghana.
Steven N ChillrudLamont-Doherty Earth Observatory of Columbia University, Palisades, New York, NY 10964, United States.
Haotian WuDepartment of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, NY 10032, United States.ORCID https://orcid.org/0000-0002-6271-0249
Abigail GaylordDepartment of Environmental Health Sciences, Mailman School of Public Health at Columbia University, New York, NY 10032, United States.ORCID https://orcid.org/0000-0002-5859-6359
Cascade TuholskeDepartment of Earth Sciences, Montana State University, Bozeman, MT 59715, United States.
Kwaku Poku AsanteKintampo Health Research Centre, Kintampo, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humid heat exposures over pregnancy impact birth outcomes but mechanisms are poorly described. We leveraged the Ghana Randomized Air Pollution and Health Study (GRAPHS) to examine associations between maximum shaded wet bulb globe temperature (WBGT) and cord blood extracellular vesicle (EV)-associated microRNA. We also considered heat index (HI) and dry air temperature as secondary exposures. Cord blood was collected at delivery and EVs isolated and RNAs sequenced and small RNA libraries constructed. We assigned participants' trimester and whole pregnancy average heat exposures using satellite reanalysis heat exposures at the level of participant community of residence. We then performed linear regression to examine associations between prenatal heat exposures and log2-transformed miRNA counts and considered significance with an unadjusted

Indexed as

cord blood extracellular vesiclesheat exposuremicroRNAprenatalwet bulb globe temperature

Identifiers

PMID42273269
PMCPMC13247845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.