Evidence map›Paper›PMID 42273238›Full record

ReviewWorld journal of gastrointestinal pharmacology and therapeutics2026

Precision immunotherapy in oesophageal squamous cell carcinoma: Molecular pathogenesis and checkpoint inhibitor response prediction.

Meer M Chisthi, Sindhu Viswanath, Krishnakumar G Kuttanchettiyar

Abstract readReview
In one paragraph

Review in World journal of gastrointestinal pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meer M ChisthiDepartment of General Surgery, Government Medical College Kollam, Parippally 691574, Kerala, India. meerchisthi.m@tmc.kerala.gov.in.
Sindhu ViswanathDepartment of Ear Nose Throat, Government Medical College Trivandrum, Thiruvananthapuram 695011, Kerala, India.
Krishnakumar G KuttanchettiyarDepartment of General Surgery, Government Medical College Kollam, Parippally 691574, Kerala, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oesophageal squamous cell carcinoma (ESCC) remains a significant global health challenge due to its aggressive nature and poor prognosis. Recent advances in immunotherapy, particularly immune checkpoint inhibitors (ICIs), have revolutionized treatment paradigms. This review comprehensively examines the molecular pathogenesis of ESCC, highlighting key oncogenic pathways and immune evasion mechanisms. Furthermore, it explores the evolving landscape of biomarkers and predictive models for ICI response, emphasizing the critical role of precision immunotherapy in tailoring treatment strategies. A deeper understanding of these molecular and immunological underpinnings is essential for optimizing patient selection, overcoming resistance, and ultimately enhancing therapeutic efficacy in ESCC.

Indexed as

Immune checkpoint inhibitorsMolecular pathogenesisOesophageal squamous cell carcinomaPrecision immunotherapyPredictive biomarkersTumour microenvironment

Identifiers

PMID42273238
PMCPMC13248143

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.