Evidence map›Paper›PMID 42273222›Full record

ArticleFrontiers in plant science2026

Exogenous 24nt siRNAs induce AGO4A-dependent silencing via promoter DNA methylation and H3K9me2 deposition.

Arvid Hanke, Laura Schütz, Melanie Walz, Nadja Wunsch, Lenard Kreis, Linus Hohenwarter, Alexandra Baßler, Michele Wassenegger, Gabi Krczal, Aline Koch and 1 more

Abstract read
In one paragraph

Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arvid HankeRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Laura Schütz *RLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Melanie Walz *RLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Nadja WunschRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Lenard KreisRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Linus HohenwarterRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Alexandra BaßlerRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Michele WasseneggerRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Gabi KrczalRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.
Aline KochInstitute for Plant Sciences, Plant RNA Biotechnology, University of Regensburg, Regensburg, Germany.
Veli Vural UsluRLP Agroscience GmbH, Neustadt an der Weinstraße, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcriptional Gene Silencing (TGS) is an essential process in plants for development, gene regulation, defense against viruses, and genome integrity. TGS is predominantly established by RNA-directed DNA methylation (RdDM), a self-reinforcing mechanism in which sRNAs guide transcriptional suppressors to target genomic loci by sequence complementarity, and methylated DNA in turn facilitates sRNA genesis. Recently, exogenous application of promoter targeting long dsRNAs was associated with promoter methylation without any detectable gene silencing. A plethora of sRNAs of different sizes and types form as cleavage products of precursor dsRNAs such as pre-miRNAs, inverted-repeats, viral replication intermediates, or exogenous dsRNAs. Due to the complexity of sRNA products, the features of the sRNAs, which trigger

Indexed as

argonautDNA methylationH3K9mePTGS (post transcriptional gene silencing)SIGSsiRNA - small interfering RNATGS (transcriptional gene silencing)

Identifiers

PMID42273222
PMCPMC13246646

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.