ArticleQuantitative imaging in medicine and surgery2026
Assessment of right ventricular systolic function via the AutoStrain Right Ventricle technique in patients with ovarian cancer during early-stage chemotherapy.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chemotherapy has been established as a hazard for cardiotoxicity in patients with ovarian cancer (ovarian CA), yet its early effect on right ventricular (RV) myocardial mechanics remains underexplored. This study aimed to investigate the clinical utility of the AutoStrain RV technique in the early assessment of RV systolic function in patients with ovarian CA receiving chemotherapy. Methods: This prospective study included 35 postoperative patients with ovarian CA receiving first-line paclitaxel-carboplatin chemotherapy and 40 age- and sex-matched healthy controls. All participants underwent comprehensive transthoracic echocardiography. For the patient group, examinations were performed at three time points: before chemotherapy (T0), after three cycles of chemotherapy (T1), and after six cycles of chemotherapy (T2). The AutoStrain RV technique was applied to measure RV global and segmental longitudinal strain parameters. Intragroup differences across the three time points were analyzed via repeated-measures analysis of variance (ANOVA), and the diagnostic performance was evaluated via receiver operating characteristic (ROC) curve analysis. Results: Compared with baseline (T0), all RV strain parameters were significantly reduced as early as T1 and declined further at T2 (all P values <0.001). Apical RV free wall longitudinal strain decreased from -25.58% at T0 to -22.19% at T1 and -20.08% at T2. Conventional RV functional parameters remained unchanged at T1 but were significantly decreased at T2 (P<0.05). Among the parameters, apical RV free wall longitudinal strain yielded the highest area under the curve (AUC) at T1 and T2, with values of 0.806 (specificity 82.86%) and 0.902 (specificity 97.14%), respectively. Conclusions: The AutoStrain RV technique allows for the early postoperative assessment of RV systolic impairment in patients with ovarian CA undergoing chemotherapy with paclitaxel plus carboplatin.
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