ArticleQuantitative imaging in medicine and surgery2026
Association of TERT promoter mutation and MGMT methylation with MRI features and overall survival in glioblastoma, IDH-wildtype.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Glioblastomas have a poor prognosis. Molecular markers such as telomerase reverse transcriptase promoter (TERTp) and O6-methylguanine-DNA methyltransferase (MGMT) impact tumor behavior and prognosis. However, their relationship with magnetic resonance imaging (MRI) characteristics and prognosis remains poorly understood. This study aimed to investigate the association between TERTp and MGMT with MRI features and overall survival (OS) in glioblastomas. Methods: This retrospective study included 194 patients with glioblastoma who underwent preoperative 3.0 Tesla (T) MRI. A total of 11 morphologic image features were visually assessed, and quantitative parameters-including the minimum apparent diffusion coefficient value (ADC Results: TERTp mutation (TERTpm) was associated with older age in glioblastoma. Tumors harboring TERTpm showed significantly greater enhancement (P<0.001), tumor mass effect (P=0.009), lower rADC Conclusions: This study demonstrates that TERTpm and MGMTm are closely associated with MRI features and OS in glioblastomas. MRI characteristics provide a promising non-invasive tool for predicting TERTpm status, whereas MGMTm serves as an independent prognostic marker for glioblastomas. These findings provide new insights for the early diagnosis of glioblastomas.
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