ArticleFrontiers in microbiology2026
Decoupling sporulation from insecticidal activity in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The persistence of Objectives: The aim of this study was to generate and characterize novel oligosporogenic mutants of the Methods: Successive sequential rounds of UV irradiation (254 nm) were applied, and mutants were screened for reduced sporulation while maintaining crystal production. Two promising candidates, T3 and T8, were selected for kinetic studies, protein quantification, and bioassays against five major lepidopteran pests. Their genomes were sequenced using Illumina technology and subjected to comparative genomic analysis. Results: Both mutants exhibited a significant delay in sporulation and altered glucose consumption patterns compared to the wild-type BLB1 strain. Despite the reduction in spore counts (5 × 10 Conclusion: These findings demonstrate that iterative UV mutagenesis effectively decoupled sporulation from insecticidal activity. The resulting mutants, T3 and T8, represent promising candidates for safer and more effective commercial biopesticide applications, combining reduced environmental persistence with strong biocontrol efficacy.
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