ArticleFrontiers in microbiology2026
Purification, characterization, and anticoagulant mechanism of an anticoagulant protein from marine
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anticoagulants are the primary drugs for the prevention and treatment of thromboembolism. However, most currently available anticoagulants have certain limitations, and there is an urgent need for novel anticoagulants. Marine microorganisms represent a valuable reservoir for the discovery of novel drugs. A marine microorganism capable of producing an anticoagulant protein was isolated from the mangrove mudflat sediment in Beihai City, China. The strain was classified and identified based on 16S rRNA gene sequencing and sequence alignment, combined with phenotypic characteristics. The anticoagulant protein was isolated and purified by ammonium sulfate precipitation, DEAE Sepharose Fast Flow anion exchange chromatography, and Sepharose CL-6B gel filtration chromatography. Its molecular weight was determined by SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis) and COSMOSIL 5Diol-120-II gel filtration chromatography. Physicochemical properties, hemolytic safety, and the effect on erythrocyte aggregation were also examined. To evaluate its anticoagulant effect,
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