Evidence map›Paper›PMID 42273014›Full record

ArticleDermatology research and practice2026

The Role of

Xiaojin Liu, Lei Chang, Yaqian Qiu, Xiaobing Lv, Tiancheng Ji

Abstract read
In one paragraph

Article in Dermatology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Molecules (Basel, Switzerland) · 2026
    Article
  2. The Role ofDermatology research and practice · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaojin LiuAnhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China, ahnu.edu.cn.ORCID https://orcid.org/0000-0002-6574-7856
Lei ChangAnhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China, ahnu.edu.cn.ORCID https://orcid.org/0000-0003-0937-4183
Yaqian QiuAnhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China, ahnu.edu.cn.ORCID https://orcid.org/0009-0008-7707-1911
Xiaobing LvAnhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China, ahnu.edu.cn.ORCID https://orcid.org/0000-0002-9103-0517
Tiancheng JiAnhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Metabolic Diseases, College of Life Sciences, Anhui Normal University, Wuhu, 241000, Anhui, China, ahnu.edu.cn.ORCID https://orcid.org/0000-0003-0537-2826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Hair graying, often linked to aging (oxidative stress), has gained significant attention due to its social implications and the desire for a youthful appearance. Currently, there is no effective solution. The objective of this study was to determine whether Methods: Oxidative stress models were established using B16 melanoma cells and C57BL/6 mice. GP treatment's effects on cell viability, melanocyte apoptosis, intracellular reactive oxygen species (ROS) levels, melanin production, tyrosinase activity, total superoxide dismutase (SOD) activity, and the Wnt/β-catenin signaling pathway were assessed. In animal experiments, the protective effects of GP on mouse hair follicles were evaluated. Results: GP treatment enhanced cell viability, decreased melanocyte apoptosis, reduced intracellular ROS levels, increased melanin production, boosted tyrosinase and SOD activity, and potentially modulated the Wnt/β-catenin signaling pathway. In animal experiments, GP significantly protected mouse hair follicles from H Conclusion: The findings suggest that GP has potential as a treatment for hair graying by mitigating H

Indexed as

Gynostemma pentaphyllum (Thunb.) Makino extracthair grayingmelanocytesoxidative stressWnt/β-catenin signaling pathway

Identifiers

PMID42273014
PMCPMC13247306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.