Evidence map›Paper›PMID 42272974›Full record

ArticleBioengineering & translational medicine2026

Physiological and functional characterization for high-throughput optogenetic skeletal muscle exercise assays.

Ronald H Heisser, Angel Bu, Laura Schwendeman, Tamara Rossy, Pavankumar Umashankar, Vincent Butty, Ritu Raman

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronald H HeisserDepartment of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA.
Angel BuDepartment of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA.
Laura SchwendemanDepartment of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA.
Tamara RossyDepartment of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA.
Pavankumar UmashankarDepartment of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA.
Vincent ButtyKoch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge Massachusetts USA.
Ritu RamanDepartment of Mechanical Engineering Massachusetts Institute of Technology Cambridge Massachusetts USA.ORCID https://orcid.org/0000-0001-8657-9815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise promotes human mobility by tuning the function of skeletal muscle, and recent studies highlight exercise's broader impacts on human health via muscle's paracrine and endocrine roles beyond force generation. In vitro models of tissue engineered skeletal muscle enable precise investigation of adaptation to exercise, with emerging approaches for optogenetic muscle stimulation providing a less invasive alternative to traditional techniques for electrical stimulation. In this study, we present a high-throughput muscle culture and optical exercise protocol for scalable in vitro exercise studies. First, we characterize optical rheobase for 2D muscle monolayers, finding that optical intensities as low as 5 μW mm

Indexed as

exerciseoptogeneticsskeletal muscletissue engineering

Identifiers

PMID42272974
PMCPMC13247415

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.