Evidence map›Paper›PMID 42272967›Full record

ArticleBioengineering & translational medicine2026

Staphylococcal proliferation on skin models to investigate novel anti-infective treatments against dysbiosis.

Sarah Frisch, Samy Aliyazdi, Jacqueline Rehner, Georges Schmartz, Caroline Gevaerd, Lorenz Latta, Barbara Veldung, Sören L Becker, Andreas Keller, Ulrich F Schaefer and 3 more

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sarah FrischHelmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research Saarbrücken Germany.ORCID https://orcid.org/0000-0003-2149-580X
Samy AliyazdiHelmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research Saarbrücken Germany.
Jacqueline RehnerSaarland University Saarbrücken Germany.
Georges SchmartzSaarland University Saarbrücken Germany.
Caroline GevaerdClinic for Dermatology, Venereology, and Allergology Homburg Germany.
Lorenz LattaHelmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research Saarbrücken Germany.
Barbara VeldungSpecialist in Plastic and Aesthetic Surgery Saarbrücken Germany.
Sören L BeckerSaarland University Saarbrücken Germany.ORCID https://orcid.org/0000-0003-3634-8802
Andreas KellerSaarland University Saarbrücken Germany.
Ulrich F SchaeferSaarland University Saarbrücken Germany.
Brigitta LoretzHelmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research Saarbrücken Germany.ORCID https://orcid.org/0000-0003-0057-5181
Thomas VogtClinic for Dermatology, Venereology, and Allergology Homburg Germany.
Claus-Michael LehrHelmholtz-Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research Saarbrücken Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory skin conditions like Acne inversa are characterized by dysbiosis, an imbalance of commensal and pathogenic bacteria, posing challenges for specific treatments. Consequently, we investigated how biofilm formation, low-nutrition skin environments, and air interfaces influence susceptibility to anti-infective treatments in mixed bacterial cultures. To achieve this in a cost-effective and reproducible manner, we developed a simplified substrate made of gelatin, hyaluronic acid, chondroitin sulphate, and alginate (=Gel-Alg). This in vitro model simulates biofilm cultivation on skin surfaces for aerobic bacteria. We selected

Indexed as

antibiotic tolerancebacterial infectionbiofilmhidradenitis suppurativain vitro modelsmicrobiomerhamnolipids

Identifiers

PMID42272967
PMCPMC13247412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.