Evidence map›Paper›PMID 42272941›Full record

ArticleNature health2026

Role of community and sexual contacts as drivers of MPXV clade I.

Hiroaki Murayama, Toshiaki R Asakura, Borame L Dickens, Dorothy Boyle, Jen Han Foo, Shihui Jin, Patrick K Mukadi, Keisuke Ejima, Sung-Mok Jung, Akihiro Nishi and 5 more

Abstract read
In one paragraph

Article in Nature health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Hiroaki Murayama *School of Medicine, International University of Health and Welfare, Narita, Japan.ORCID 0000-0002-7219-5981
Toshiaki R Asakura *Department of Infectious Disease Epidemiology and Dynamics, London School of Hygiene and Tropical Medicine, London, UK.
Borame L DickensSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Dorothy BoyleSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Jen Han FooSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Shihui JinSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Patrick K MukadiDepartment of Epidemiology and Global Health, Institut National de Recherche Biomedical (INRB), Kinshasa, Democratic Republic of the Congo.ORCID 0000-0001-9312-9345
Keisuke EjimaLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0002-1185-3987
Sung-Mok JungSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.ORCID 0000-0002-0787-4515
Akihiro NishiDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA USA.ORCID 0000-0003-1629-5985
Kiesha PremCentre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Audry M WakambaMinistry of Health, National Expanded Program for Immunization, Kinshasa, Democratic Republic of the Congo.
Diafuka Saila-NgitaDepartment of Basic Sciences, Faculty of Veterinary Medicine, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.
David NiyukuriDoctoral School, University of Burundi, Bujumbura, Burundi.
Akira EndoDepartment of Infectious Disease Epidemiology and Dynamics, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-6377-7296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Initial investigation into the emerging mpox outbreak caused by novel monkeypox virus (MPXV) clade Ib in the eastern Democratic Republic of the Congo has identified signs of sustained human-to-human transmission and epidemiological links to sexual contacts involving female sex workers (FSWs), which have not been observed in previous clade Ia outbreaks. Using mathematical models incorporating age-dependent contact patterns, we quantified the role of frequent sexual interactions as opposed to community contacts in clade Ib's dynamics and found that this additional mode of transmission could explain its increased outbreak potential compared with clade Ia. As with the globally circulating clade IIb, which is transmitted predominantly among men who have sex with men, our findings reinforce the importance of protecting key population groups-specifically FSWs for clade Ib-in controlling ongoing mpox outbreaks.

Indexed as

EpidemiologyViral infection

Identifiers

PMID42272941
PMCPMC13246439

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.