ArticleWorld journal of critical care medicine2026
High-flow nasal cannula for hypoxia in the post-anesthetic recovery unit: A systematic review and meta-analysis.
Article in World journal of critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
backgroundEarlier meta-analyses demonstrated conflicting results on whether high-flow nasal cannula (HFNC) reduces rate of intubation in the postoperative period when compared to conventional oxygen therapy (COT). Since then, newer studies have come out, so an updated comparison of these two modalities is warranted.
aimTo determine whether HFNC reduces the rate of reintubation compared to COT.
methodsWe conducted a random-effects meta-analysis, searching databases (MEDLINE, EMBASE, Web of Science) to identify randomized controlled trials comparing HFNC with COT on postoperative patient outcomes of interest including reintubation, escalation to noninvasive ventilation, mortality, length of stay, pneumonia, postoperative pulmonary complications, vital signs and blood gas measurements. We assessed the quality of data using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.
resultsTwenty-five trials, including 4260 patients met the inclusion criteria. Thirteen investigated reintubation and the pooled result was not significant [odds ratio (OR); 0.93; 95% confidence interval (CI): 0.36-2.38;
conclusionHFNC does not reduce reintubation risk in our analysis with moderate certainty. Use of HFNC should not delay escalation of therapy to noninvasive ventilation or a definitive airway.
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