ArticleWorld journal of critical care medicine2026
Paroxysmal supraventricular tachycardia associated with dexmedetomidine withdrawal in an adult liver transplant recipient: A case report.
Article in World journal of critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDexmedetomidine is a selective α CASE SUMMARY: A woman in her 60 years was readmitted to the ICU for septic shock following liver transplantation. Prolonged high-dose dexmedetomidine infusion was required to manage sleep disturbance and anxiety. Two hours after abrupt discontinuation of dexmedetomidine, the patient developed paroxysmal supraventricular tachycardia that was refractory to adenosine triphosphate and landiolol. Reinitiation of dexmedetomidine promptly restored sinus rhythm, suggesting withdrawal-related sympathetic overactivity as the precipitating mechanism. Gradual tapering prevented recurrence.
conclusionDexmedetomidine withdrawal should be considered in adult ICU patients presenting with unexplained tachyarrhythmia. Careful tapering and multimodal sedation strategies are essential when prolonged dexmedetomidine administration is anticipated.
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