Evidence map›Paper›PMID 42272874›Full record

ArticleWorld journal of critical care medicine2026

Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial.

Chakkaravarthe Anbarasan, Ankur Sharma, Nikhil Kothari, Tanvi M Meshram, Kamlesh Kumari, Shilpa Goyal, Pradeep K Bhatia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Chakkaravarthe AnbarasanDepartment of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342005, Rājasthān, India.
Ankur SharmaDepartment of Trauma and Emergency (Anaesthesiology and Critical Care), All India Institute of Medical Sciences, Jodhpur 342008, Rājasthān, India. ankuranaesthesia@gmail.com.
Nikhil KothariDepartment of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342005, Rājasthān, India.
Tanvi M MeshramDepartment of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342005, Rājasthān, India.
Kamlesh KumariDepartment of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342005, Rājasthān, India.
Shilpa GoyalDepartment of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342005, Rājasthān, India.
Pradeep K BhatiaDepartment of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur 342005, Rājasthān, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is associated with impaired tissue perfusion and elevated serum lactate, a key prognostic marker. Magnesium plays a vital role in cellular energy metabolism and may enhance lactate clearance in sepsis.

aimTo investigate the impact of magnesium on the clearance of lactate in critically sick patients with sepsis.

methodsIn this triple-blind, randomized trial, 138 adult patients with a diagnosis of sepsis (according to Sepsis-3 guidelines) and with serum lactate levels > 2 mmol/L were randomized into the magnesium (M) group and the placebo (P) group. Randomization was performed using an online sequence generator. The individuals in group M were administered 2 g of magnesium sulphate infusion diluted in 50 mL of normal saline over 2 hours for 3 days. The individuals in group P were administered an identical volume of normal saline for three days. The primary outcome was to compare the time to lactate clearance (20% decrease from baseline) in both groups. The secondary outcomes included changes in lactate clearance, intensive care unit (ICU) duration, hospital stay, and 28-day mortality in both groups.

resultsTime to 20% lactate clearance was considerably lower in the M group (5.73 ± 2.19 hours) when compared to the P group (8.54 ± 2.72 hours), with a mean difference [95% confidence interval (CI)]: -2.81 (-3.65 to -1.99),

conclusionMagnesium supplementation was associated with shorter lactate clearance time and reduced ICU and hospital stay duration in patients with sepsis; however, the difference in 28-day mortality between the groups was statistically nonsignificant.

Indexed as

Intensive care unitLactateLactate clearanceMagnesiumSepsis

Identifiers

PMID42272874
PMCPMC13248059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.