ArticleBrain communications2026
Glymphatic system bridges peripheral and central nervous system changes in classic trigeminal neuralgia.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Classical trigeminal neuralgia exhibits both peripheral neurovascular compression and widespread central white matter alterations, but the mechanisms bridging peripheral and central pathology remain elusive. This study investigated the role of glymphatic system dysfunction in linking peripheral and central pathology. We prospectively enrolled 115 classical trigeminal neuralgia patients and 87 healthy controls, using advanced multi-shell diffusion MRI to assess microstructural integrity (via neurite orientation dispersion and density imaging metrics) and glymphatic function (via the diffusion tensor imaging along the perivascular space index). Results demonstrated significant microstructural alterations at neurovascular compression sites, including lower fractional anisotropy and neurite density index, along with a higher fraction of isotropic water in affected trigeminal nerves compared to the unaffected sides and healthy controls (
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