ArticleFrontiers in pharmacology2026
Clove (
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Introduction: Clove ( Methods: We used an imiquimod (IMQ)-induced mouse model to assess the effects of oral clove extract and eugenol. Proteomic alterations were identified via isobaric tags for relative and absolute quantitation-based liquid chromatography-tandem mass spectrometry and bioinformatics. The specific interaction with the interleukin-17A (IL-17A)/IL-17 receptor A (IL-17RA) interface was validated through competitive binding assays and molecular docking, with further confirmation via immunohistochemistry. Results: Eugenol was identified as the major constituent of clove extract (65.8%). Clove extract and eugenol significantly alleviated psoriasiform lesions, reducing scaling scores and epidermal thickness. Proteomic analysis revealed that both treatments reversed IMQ-induced inflammatory signatures by modulating the interleukin-36 (IL-36) and IL-17 signaling pathways, specifically increasing IL-36 receptor antagonist expression while suppressing IL-36 levels. Conclusion: Clove extract and its major bioactive constituent eugenol exert significant anti-psoriatic effects through coordinated modulation of the IL-36/IL-17A inflammatory axis and suppression of NF-κB signaling. These findings provide mechanistic insight into the traditional use of clove in inflammatory skin disorders and highlight eugenol as a key bioactive mediator with potential as a complementary therapeutic strategy for psoriasis.
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