ReviewOncoscience2026
Adaptor proteins regulating tumor-associated macrophage polarization during cancer progression.
Review in Oncoscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Adaptor proteins serve as essential molecular scaffolds within the tumor microenvironment, linking activated receptors to downstream signaling pathways and coordinating the assembly of multiprotein complexes that modulate immune responses. Emerging evidence suggests that adaptor proteins play a critical role in shaping macrophage phenotypic plasticity. Tumor-associated macrophages exhibit functional heterogeneity and can adopt either anti-tumorigenic phenotypes that promote immune activation or pro-tumorigenic phenotypes that support tumor growth, metastasis, and immune evasion. The dynamic transition between these functional states is tightly controlled by intracellular signaling networks in which adaptor proteins function as key regulatory nodes. Based on available mechanistic studies, we systematically summarize adaptor molecules that govern signaling pathways driving macrophage polarization within the cancer condition. Additionally, this review underscores the significance of adaptor proteins as key modulators of macrophage phenotype and highlights their potential as therapeutic targets for reprogramming macrophages to enhance anti-tumor immunity. Collectively, we provide a conceptual framework for understanding adaptor-mediated immune regulation in cancer and support the development of targeted strategies to shape the tumor microenvironment.
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