ArticleOncology letters2026
Development and validation of a prognostic nomogram incorporating preoperative NLR, CEA and CA19-9 for overall survival in colorectal cancer.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Reliable evaluation methods serve an important role in improving the prognosis of patients with colorectal cancer (CRC), guiding the development of treatment plans and prolonging patient survival. In the present study, several preoperative inflammatory indicators and tumor markers were evaluated for their ability to predict CRC prognosis. A total of 224 eligible patients with CRC were enrolled and divided into the training (n=150) and validation (n=74) groups. The training group underwent both Least Absolute Shrinkage and Selection Operator (LASSO) regression and Cox regression analyses to discern pivotal prognostic factors, to formulate a nomogram for overall survival prediction. The results showed that LASSO regression, along with univariate and multivariate Cox regression analyses, identified neutrophil-lymphocyte ratio (NLR), carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) as effective risk factors for CRC. The concordance index of the nomogram was 0.716 in the training group and 0.700 in the validation group. The areas under the curve for predicting 3-year survival were 0.748 and 0.776 in the training and validation groups, respectively, and for 5-year survival were 0.749 and 0.731, respectively. In conclusion, NLR, CA19-9 and CEA may serve as effective additions to traditional clinical assessment methods and a nomogram incorporating these three preoperative indicators could be used efficiently to predict the prognosis of patients with CRC.
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