ArticleFrontiers in pain research (Lausanne, Switzerland)2026
Clinical study of the preventive effect of pulsed radiofrequency and continuous epidural block on postherpetic neuralgia: a randomized controlled trial.
Article in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: In this study, patients with acute herpes zoster neuralgia were respectively treated with continuous epidural block and pulsed radio frequency therapy to compare the similarities and differences of the two treatment methods in preventing the incidence of PHN, as well as the efficacy of acute herpes zoster neuralgia and observe the surgical complications. Methods: Ninety patients with herpes zoster neuralgia whose course of disease was less than 1 month were randomly divided into two groups according to the type of surgery: Continuous Epidural Block (CEB group) and Pulsed Radio Frequency (PRF group). The incidence of PHN in January, March and June was recorded. VAS scores, PSQI scores and the dosage of gabapentine capsules and Tramadol hydrochloride sustained-release tablets were recorded before surgery and 1 day, 1 week, 1 month, 3 months and 6 months after surgery. Peripheral blood Gal-3 and IL-6 levels before surgery, 1 week, 2 weeks and 4 weeks after surgery; Surgical complications; The duration of hospital stay and so on were used to evaluate the clinical effect of the operation. Results: The incidence of PHN in CEB group at 1 month, 3 months and 6 months after surgery was lower than that in PRF group, and the differences were statistically significant ( Conclusions: Both methods can significantly relieve the pain of patients with acute herpes zoster neuralgia and reduce the incidence of PHN, but there is a risk of puncture site infection., and long hospital stay. PRF treatment has short hospital stay, less injury and strong repeatability.
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