Evidence map›Paper›PMID 42272758›Full record

ArticleFrontiers in cellular and infection microbiology2026

The serine-arginine-rich protein PfSR-X2 modulates human malaria parasite gene expression during the intraerythrocytic developmental cycle.

Ye Hu, Chunyu Zhuang, Mengyu Li, Jiawei Wu, Lili Zhou, Minghao Li, Xinyue Li, Xuli Du, Xiaomin Shang, Yanli Bai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ye Hu *Department of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Chunyu Zhuang *Department of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Mengyu Li *Department of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Jiawei WuDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Lili ZhouDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Minghao LiDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Xinyue LiDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Xuli DuDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Xiaomin ShangDepartment of Parasitology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Yanli BaiDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Dezhi ZhaoDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.
Shenbo ChenNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission of the People's Republic of China (NHC) Key Laboratory of Parasite and Vector Biology, World Health Organization (WHO) Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.
Yanting FanDepartment of Parasitology, School of Medicine, and Department of Blood Transfusion, Xi'an International Medical Center Hospital, Northwest University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malaria, caused by Methods: PfSR-X2 was characterized by sequence analysis, structural prediction, expression profiling, and subcellular localization assays. A glucosamine-inducible Results: PfSR-X2 was expressed throughout the intraerythrocytic developmental cycle and localized to both nuclear and cytoplasmic compartments. Attempts to disrupt Conclusion: These findings identify PfSR-X2 as an essential RNA-associated regulator in

Indexed as

ErythrocytesGene Expression RegulationMalaria, FalciparumPlasmodium falciparumProtozoan ProteinsRNA-Binding ProteinsAlternative SplicingGene Expression ProfilingGene Knockdown TechniquesHumansLife Cycle StagesProtozoan ProteinsRNA-Binding ProteinsApiAP2 gene familyPfSR-X2Plasmodium faciparumpost transcriptional regulationrif multigene familyRNA bind protein

Identifiers

PMID42272758
PMCPMC13247540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.