ArticleSmall science2026
Entry Without Expression: Internalisation Does Not Predict mRNA Translation for Targeted Lipid Nanoparticles.
Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid nanoparticle (LNP) delivery systems offer efficient encapsulation and protection of mRNA, making them a popular platform in nucleic acid therapeutics, including mRNA vaccines. Conventional LNPs rely on non-specific cellular interactions and internalisation which can result in poor delivery to target cells and increased off-target delivery. Surface functionalization of LNPs with antibodies can enhance target cell accumulation, reducing off target effects. However, selecting antibody-receptor pairs based on abundance does not result in optimal delivery. Here, we present a novel approach to quantify internalisation and mRNA delivery efficiency of antibody-functionalised LNP/mRNA in primary human T and B cells. By targeting LNPs to a range of clinically relevant T and B cell receptors, we demonstrate that LNP internalisation does not necessarily predict successful mRNA delivery. Our findings highlight that receptor mediated internalisation can improve targeted delivery of LNPs, however favourable receptor-specific post-internalisation trafficking of LNP/mRNA is critical to successful cytosolic mRNA release and translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.