ArticleFrontiers in pediatrics2026
Implementation of exclusive enteral nutrition in pediatric Crohn's disease: a secondary analysis of the CLARA registry study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Exclusive enteral nutrition (EEN) is the first-line therapy for children with active luminal Crohn's disease (CD). However, its implementation in routine care is still limited. Given the impact of the disease on age-appropriate development and quality of life in children and adolescents, as well as the rising incidence rates, the use of this effective and low-risk therapy should be intensified. Previous studies have demonstrated that patient registries can provide support in following guideline-based care. This study represents a secondary analysis of the CLARA cluster-randomized trial and aims to describe real-world patterns of enteral nutrition (EN) use and implementation gaps for children with luminal CD. Methods: This secondary analysis was based on data from a cluster-randomized, controlled trial (DRKS00015505). In the intervention group (IG), treatment providers documented the care of children and adolescents with inflammatory bowel disease (IBD) in the CEDATA-GPGE patient registry and received automated feedback on entered data and potential deviations from guideline recommendations (care deficits). In the control group (CG), treatments were documented as usual in patients' charts only. For this secondary analysis, initial treatment strategies for children with luminal CD during the first 90 days after diagnosis were compared between centers with registry-based documentation (IG) and those without (CG). The primary outcome was the documented use and pattern of EN, including the duration of EEN and combination therapies. Results: Of the 319 children recruited (IG: 21 centers, Conclusion: Registry documentation was associated with a non-significant increase in overall EN use but did not improve adherence to guideline-recommended EEN. The findings highlight a substantial gap between guideline recommendations and real-world implementation of EEN, underscoring the need to address structural, professional, and patient-related barriers.
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