ArticleAesthetic surgery journal. Open forum2026
Vitamin D Deficiency as a Risk Factor for Hypertrophic Scarring and Reconstructive Surgeries After Burns.
Article in Aesthetic surgery journal. Open forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background: Vitamin D plays an important role in immune regulation, collagen remodeling, and wound healing. In the general population, deficiency has been associated with poor wound repair and fibrosis, yet evidence in burn patients remains limited. Burn injuries often result in hypertrophic scarring and significant healthcare utilization for reconstructive and adjunctive procedures. Objectives: This study examines the impact of preexisting vitamin D deficiency on hypertrophic scarring and scar-related healthcare utilization in a large, multi-institutional cohort of burn patients. Methods: The TriNetX Research Network was queried for patients ≥18 years old with burn injuries between 2010 and 2023. Patients with vitamin D deficiency, defined as 25-hydroxyvitamin D <20 ng/mL within 1 month before injury, were matched 1:1 to nondeficient controls using propensity score matching. Matching variables included demographics, BMI, comorbidities, substance use, vitamin deficiencies (A, C, E, and K), calcidiol levels, and total burn surface area. The primary outcome was hypertrophic scarring. Secondary outcomes included scar-related interventions: Z-plasty and intralesional corticosteroid injections. Cumulative incidence was assessed at 3, 12, and 24 months. Hazard ratios (HRs) with 95% CIs were calculated using Cox proportional hazards models. Results: After matching, 6832 patients were included in each cohort. Vitamin D deficiency was associated with significantly higher rates of hypertrophic scarring at 3 months (5.82% vs 2.55%, HR 2.33, 95% CI, 1.93-2.81, Conclusions: Vitamin D deficiency is strongly associated with increased hypertrophic scarring and greater reliance on reconstructive and adjunctive procedures following burn injury. These results underscore the potential role of micronutrient status in long-term burn recovery. Prospective studies are needed to determine whether early detection and correction of deficiency can mitigate scarring and reduce healthcare utilization. Level of Evidence 3 Risk: For image description, please refer to the figure legend and surrounding text.
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