Evidence map›Paper›PMID 42272638›Full record

ArticleFrontiers in cell and developmental biology2026

ARMC2 loss impairs cilia structure and leads to primary ciliary dyskinesia symptoms in mouse organs.

Elsa Giordani, Solène Houdeline, Magali Court, Sylvie Gory-Fauré, Jean-Christophe Deloulme, Anne-Pascale Bouin, Fabrice Senger, Charles Coutton, Edgar Del Llano, Anne-Laure Barbotin and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Elsa Giordani *Institute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Solène Houdeline *Institute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Magali CourtInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Sylvie Gory-FauréGrenoble Institut Neurosciences (GIN), University Grenoble Alpes, Inserm, U1216, Grenoble, France.
Jean-Christophe DeloulmeGrenoble Institut Neurosciences (GIN), University Grenoble Alpes, Inserm, U1216, Grenoble, France.
Anne-Pascale BouinInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Dynamique de l'adhésion cellulaire et différentiation, Grenoble, France.
Fabrice SengerInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Dynamique de l'adhésion cellulaire et différentiation, Grenoble, France.
Charles CouttonInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Edgar Del LlanoInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Anne-Laure BarbotinLaboratory of Development and Plasticity of the Postnatal Brain, University Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S1172, FHU 1000 days for health, Lille, France.
Angèle BoursierLaboratory of Development and Plasticity of the Postnatal Brain, University Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S1172, FHU 1000 days for health, Lille, France.
Geneviève ChevalierInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Anne BertrandGrenoble Institut Neurosciences (GIN), University Grenoble Alpes, Inserm, U1216, Grenoble, France.
Christophe BoscGrenoble Institut Neurosciences (GIN), University Grenoble Alpes, Inserm, U1216, Grenoble, France.
Jessica EscoffierInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Pierre F RayInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Guillaume MartinezInstitute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Christophe Arnoult *Institute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.
Corinne Loeuillet *Institute for Advanced Biosciences, University Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans and mice, deficiency in ARMC2 causes Multiple Morphological Abnormalities of the Flagellum (MMAF), a condition defined by absent or aberrant sperm flagella with a disorganized axoneme. Affected men are infertile but with no other obvious signs characteristics/typical for primary cilia dyskinesia (PCD). Given the similarity between cilia and flagella axonemes we investigated a possible role of ARMC2 in cilia functioning. In

Indexed as

ARMC2ciliaMMAFPCDsperm flagella

Identifiers

PMID42272638
PMCPMC13246696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.