Evidence map›Paper›PMID 42272558›Full record

ReviewRSC advances2026

Role of polymeric nanocomposite for tissue engineering applications.

Shivakumar Naik, Uma Palanikumar, Amgoth Ramesh, Udayakumar D, B C Revanasiddappa, Harishkumar Madhyastha, Akhil Nair, Wilona Loren Lobo, Pavithra Pradeep Prabhu

Abstract readReview
In one paragraph

Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shivakumar NaikDepartment of Chemistry, National Institute of Technology Karnataka Surathkal Mangalore-575025 Karnataka India udayakumar@nitk.edu.in udayaravi80@gmail.com.ORCID https://orcid.org/0009-0007-4312-1717
Uma PalanikumarDepartment of Plant Biotechnology, Center for Plant Molecular Biology and Biotechnology, Agricultural University Tamil Nadu India.
Amgoth RameshDepartment of Chemistry, National Institute of Technology Karnataka Surathkal Mangalore-575025 Karnataka India udayakumar@nitk.edu.in udayaravi80@gmail.com.
Udayakumar DDepartment of Chemistry, National Institute of Technology Karnataka Surathkal Mangalore-575025 Karnataka India udayakumar@nitk.edu.in udayaravi80@gmail.com.
B C RevanasiddappaNitte (Deemed to Be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS Department of Pharmaceutical Chemistry Mangalore India revan@nitte.edu.in.
Harishkumar MadhyasthaDepartment of Cardiovascular Physiology, University of Miyazaki Miyazaki Japan.ORCID https://orcid.org/0000-0002-7143-4821
Akhil NairNitte (Deemed to Be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutics Mangalore India.
Wilona Loren LoboNitte (Deemed to Be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmacology Mangalore India.ORCID https://orcid.org/0009-0001-2053-5980
Pavithra Pradeep PrabhuDepartment of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education Manipal Karnataka 576104 India pavithra.prabhu@manipal.edu.ORCID https://orcid.org/0000-0003-0585-6329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymeric nanocomposites have become revolutionary biomaterials for tissue engineering due to their unparalleled tunability by combining the design flexibility of polymeric matrices and functional properties of nano-fillers. This review provides a critical discussion of the principles of designing, synthesizing, fabricating, characterizing, and applying polymeric nanocomposites towards the tissue engineering purpose. The latest achievements in polymeric nanocomposites such as artificial intelligence-based scaffold design, clinical implementation of collagen-based nerve conduit, and novel stimuli-responsive 4D nanocomposites are analyzed in detail based on their importance to the field. Instead of a mere listing of materials, the review offers a comprehensive comparison between different approaches towards fabricating polymeric nanocomposites depending on their application towards different types of tissues, characterization, and clinical applications. The regulatory aspects and current barriers towards translating these materials into clinics are discussed as well. Finally, the review offers specific predictions about the three most promising polymer-nano filler combinations and three major challenges to this field within the next five years.

Identifiers

PMID42272558
PMCPMC13247827

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.