Evidence map›Paper›PMID 42272524›Full record

ReviewFundamental research2026

Crosstalk between bone and vasculature within bone.

Wenyu Xia, Wei Wang, Yi Qin, Yayun Ding, Wenhao Li, Gaoran Ge, Wenming Li, Wei Zhang, Huilin Yang, Liangliang Wang and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Recapitulation ofJournal of orthopaedic translation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenyu XiaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Wei WangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yi QinDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yayun DingDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Wenhao LiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Gaoran GeDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Wenming LiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Wei ZhangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Huilin YangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Liangliang WangDepartment of Orthopedics, The Affiliated Changzhou No 2 People's Hospital of Nanjing Medical University, Changzhou 213000, China.
Jiaxiang BaiDepartment of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230022, China.
Dechun GengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone is a highly vascularized connective tissue, and its physiological and pathological processes are closely linked to the vascular system. The vasculature system should include the blood vessel system and the lymphatic system, while the majority of previous reviews only discuss the relationship between bone and blood vessels. Vascular vessels travel through the bone and constitute the bone microenvironment together with the bone structure. The paracrine function of the vasculature is essential for bone development, homeostasis, regeneration, modeling, and remodeling. Osteolineage cells also regulate the physiologic activity of the vascular system. Complex signaling crosstalk exists between the vascular system and bone and together coordinate the dynamic processes of bone formation and bone resorption. In addition, targeting based on the skeletal-vasculature axis also provides new strategies for the therapy of related diseases.

Indexed as

AngiogenesisBlood vesselsBone remodelingLymphatic VesselsVasculature

Identifiers

PMID42272524
PMCPMC13247514

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.