ArticleFundamental research2026
Modulation of place cells using targeted stimulation with bidirectional microelectrode arrays enhances spatial learning speed in mice.
Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Spatial cognition plays a critical role in survival and development, yet effective technologies for enhancing this capability remain scarce. This study investigates a neural modulation approach targeting place cells-specialized hippocampal neurons responsible for spatial representation. Bidirectional microelectrode arrays with micron-level spatial precision were developed using micro-electromechanical systems technology, integrating detection, stimulation, and shielding functions. The array enables simultaneous electrophysiological recording and confined electrical stimulation while minimizing signal interference. A modified Y-maze behavioral paradigm and electrical stimulation protocol were designed to assess spatial learning enhancement. Experimental results demonstrated that mice receiving 72 mV/90 Hz electrical stimulation through the array achieved comparable place cell activation patterns and behavioral performance after 1 week of training to control mice requiring 2 weeks of conventional training. Quantitative analysis revealed a 19.7% increase in learning trajectory success rate, 50.2% increase in spatial information, and 25.1% reduction in area of place field in stimulated subjects compared to non-stimulated controls. These findings indicate that precise electrical modulation of place cell ensembles through the developed array can significantly accelerate spatial learning processes. This integrated neural interface technology provides a closed-loop solution for targeted neuromodulation, offering new possibilities for enhancing spatial cognition through direct neural circuit engagement.
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