Evidence map›Paper›PMID 42272477›Full record

ArticleFundamental research2026

Melatonin ameliorates inflammation-induced mitochondrial dysfunction and cementoblastic differentiation in cells by regulating the METTL3/LINC01444/HSPD1 axis.

Xuan Li, Bei-Min Tian, Yuan Yin, Huan Zhou, Dian Gan, Fen Liu, Jiu-Jiu Zhang, Dao-Kun Deng, Chen Jiao, Mei Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xuan LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Bei-Min TianState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Yuan YinState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Huan ZhouKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
Dian GanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Fen LiuDepartment of Pediatric Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.
Jiu-Jiu ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Dao-Kun DengState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Chen JiaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Mei XuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Li-An WuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Xiao-Tao HeState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Fa-Ming ChenState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation-induced mitochondrial dysfunction functionally impairs periodontal ligament stem cells (PDLSCs) and hinders their therapeutic efficacy in periodontal regeneration. Melatonin, a mitochondrion-targeted molecule, is considered a promising anti-inflammatory agent in therapeutics, but whether melatonin protects PDLSC cementoblastic differentiation against inflammation-induced damage and the underlying mechanisms of this function remain unclear. This study confirmed that melatonin rescued PDLSC cementoblastic differentiation under inflammatory conditions and that melatonin-induced recovery was linked to ameliorated mitochondrial function in cells. Next, through lncRNA microarray analysis, mass spectrometry and functional studies, an interaction between

Indexed as

Cementoblastic differentiationHSPD1InflammationLINC01444MelatoninMitochondrial function

Identifiers

PMID42272477
PMCPMC13247471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.