Evidence map›Paper›PMID 42272476›Full record

ReviewFundamental research2026

Discoidin domain receptor 1 (DDR1): An emerged novel mechanosensor.

Jiayu Liu, Shu Chien, Jing Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiayu LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Cardiology, Peking University Third Hospital, National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University, Beijing 100191, China.
Shu ChienDepartments of Bioengineering and Medicine, and Institute of Engineering in Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Jing ZhouDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Cardiology, Peking University Third Hospital, National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University, Beijing 100191, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell behavior is intricately influenced by the physical forces and mechanical properties of the cells and their microenvironment. Mechanotransduction plays crucial roles in the maintenance of tissue homeostasis and the development of diseases, yet the precise identity of key mechanosensory molecules and structures has been elusive. Recently, the discoidin domain receptor tyrosine kinase 1 (DDR1) has emerged as a novel mechanosensor that responds to mechanical cues such as extracellular matrix stiffness, shear stress, and cytoskeletal tension. In this review, we provide updated insights into DDR1 mechanosensing and propose future research directions. The identification of mechanosensors such as DDR1 holds promise for unlocking novel approaches for drug development to enable precision therapies that target a spectrum of diseases by modulating the mechanotransduction pathways.

Indexed as

Discoidin domain receptor 1Matrix stiffnessMechanosensorPhase separationShear stress

Identifiers

PMID42272476
PMCPMC13247511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.