Localized Accumulation of Tri-n-Propylamine Prolongs Electrochemiluminescence for Tumor Model Spheroid Analysis.

Vanshika Gupta, Megan L Hill, Samuel P Nortz, Yashvi Choudhary, Ashutosh Rana, Jeffrey E Dick

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vanshika GuptaDepartment of Chemistry, Purdue University, West Lafayette, Indiana, USA.

Megan L HillDepartment of Chemistry, Purdue University, West Lafayette, Indiana, USA.

Samuel P NortzDepartment of Chemistry, Purdue University, West Lafayette, Indiana, USA.

Yashvi ChoudharyDepartment of Chemistry, Purdue University, West Lafayette, Indiana, USA.

Ashutosh RanaDepartment of Chemistry, Purdue University, West Lafayette, Indiana, USA.

Jeffrey E DickDepartment of Chemistry, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0002-4538-9705

Funding

Department of Energy (DOE) through the University Nuclear Leadership Program Graduate FellowshipNational Science FoundationNIH HHS R35-GM138133-01

6 · The paper itself

Abstract

Electrochemiluminescence (ECL) is a technique that couples electrochemical control with photon emission, enabling highly sensitive, label-free imaging without an external light source. The microsecond lifetimes and short diffusion lengths of intermediates generated during the reaction confer excellent spatiotemporal resolution, while the absence of phototoxicity promotes biocompatibility. Previously, ECL microscopy has illuminated systems ranging from single cells to multicellular spheroids. Yet, these works relied on luminol-hydrogen peroxide chemistry, which is limited by weak signals and the sacrificial nature of luminol. Here, we introduce tris(2,2'-bipyridyl)ruthenium(II)/tri-n-propylamine ([Ru(bpy)

Indexed as

Electrochemical TechniquesLuminescent MeasurementsOrganometallic CompoundsPropylaminesSpheroids, CellularCell Line, TumorCoordination ComplexesHumansCoordination ComplexesOrganometallic CompoundsPropylaminestripropylaminetris(2,2'-bipyridyl)ruthenium(II)afterglow chemiluminescencecell spheroidselectrochemiluminescencereal‐time analysistris(2,2’‐bipyridyl)ruthenium(II)/tri‐n‐propylamine ([Ru(bpy)3]2+/TPrA)tumor analysis

Identifiers

PMID42272353

DOI10.1002/anie.8508105

PMCPMC13452574

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.