Evidence map›Paper›PMID 42272313›Full record

ArticleSmall methods2026

Functional Repurposing of Magnetic Nanoparticle-Assisted Hyperthermia for Immune Cell Labelling and Tracking.

Giulia E P Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino

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In one paragraph

Article in Small methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giulia E P NucciItalian Institute of Technology, Genoa, Italy.
Chiara VitaleDepartment of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
Alessandro di GirolamoItalian Institute of Technology, Genoa, Italy.
Niccolò SilvestriItalian Institute of Technology, Genoa, Italy.
Stefano PersanoItalian Institute of Technology, Genoa, Italy.
Lorenci GjurgjajItalian Institute of Technology, Genoa, Italy.
Cristina BottinoDepartment of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
Roberta CastriconiDepartment of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
Teresa PellegrinoItalian Institute of Technology, Genoa, Italy.ORCID https://orcid.org/0000-0001-5518-1134

Funding

AIRC project AIRC IG-29323European Research Council (Consolidator grant GIULIa ID N. 101044020 to TP
6 · The paper itself

Abstract

Immune cell therapies show promise in hematologic malignancies and are becoming more effective in solid tumors like lungs, melanoma, and colorectal cancers. Magnetic nanoparticles (MNPs) are mostly used as tracers via magnetic particle imaging(MPI) or magnetic resonance imaging(MRI), and heat mediators to monitor and kill cancer cells via magnetic hyperthermia (MHT). Here, we apply a mild-MHT protocol (38-41°C/60 min) as a new means to boost MNPs uptake by immune cells under a harmless alternating magnetic field (AMF). Various MNPs formulations, including iron oxide or zinc-ferrite compositions stabilized by different polymers, were selected for their heating performance and colloidal stability. NK-92 cell line and NK cells from healthy donors exhibited enhanced MNP internalization upon AMF exposure without compromising viability, receptor expression, and effector functions. MNP-loaded NK cells retained cytotoxic activity, degranulating upon ligand engagement on glioblastoma and neuroblastoma targets. Similar outcomes were achieved with T cells. Thanks to its simplicity, this MHT-protocol is suitable for clinical translation, as it can be straightforwardly integrated into existing GMP-compliant adoptive cell therapy workflows in a hospital cell factory, enabling the preparation of magnetically tagged immune cells ready for tracking in cell therapy infusion.

Indexed as

Cell TrackingHyperthermia, InducedKiller Cells, NaturalMagnetite NanoparticlesCell Line, TumorFerric CompoundsHumansStaining and LabelingFerric CompoundsMagnetite Nanoparticlescell labellingimmune cellsmagnetic hyperthermiamagnetic nanoparticlesmagnetic particle imaging

Identifiers

PMID42272313
PMCPMC13599683

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.